2024

A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid.

Maurat, E, K. Raasch, A. Leipold, P. Henrot, M. Zysman, R. Prevel, T. Trian, T. Krammer, V. Bergeron, M. Thumerel, P. Nassoy, P. Berger, A-E. Saliba, L. Andrique, G. Recher, I. Dupin.

Eur Respir J. 2024. DOI:10.1183/13993003.00562-2024.

2023

CXCR4 blockade alleviates pulmonary and cardiac outcomes in young COPD.

Dupin, I., P. Henrot, E. Maurat, R. Abohalaka, S. Chaigne, D.E. Hamrani, E. Eyraud, R. Prevel, P. Esteves, M. Campagnac, M. Dubreuil, G. Cardouat, C. Bouchet, O. Ousova, J.-W. Dupuy, T. Trian, M. Thumerel, H. Begueret, P.-O. Girodet, R. Martan, M. Zysman, V. Michel, and P. Berger.

BioRXiv. 2023 doi:10.1101/2023.03.10.529743.

Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research.

Nizamoglu M, Joglekar MM, Almeida CR, Larsson Callerfelt AK, Dupin I, Guenat OT, Henrot P, van Os L, Otero J, Elowsson L, Farre R, Burgess JK.

Eur Respir Rev. 2023 doi: 10.1183/16000617.0042-2023.

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response.

Eyraud, E., E. Maurat, J-M. Sac-Epée, P. Henrot, M. Zysman, P. Esteves, T. Trian, J-W. Dupuy, A. Leopold, A-E. Saliba, H. Bégueret, P-O. Girodet, M. Thumerel, R. Hustache-Castaing, R. Marthan, F. Levet, P. Vallois, C. Contin-Bordes, P. Berger, I. Dupin.

eLife. 2023 doi:10.7554/eLife.85875.

Probabilistic Cellular Automata modeling of intercellular interactions in airways: complex pattern formation in patients with Chronic Obstructive Pulmonary Disease.

Dupin, I., E. Eyraud, E. Maurat, J.-M. Sac-Épée, and P. Vallois.

Journal of Theoretical Biology. 2023. 564:111448. doi:10.1016/j.jtbi.2023.111448.

Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models.

Henrot, P., L. Blervaque, I. Dupin, M. Zysman, P. Esteves, F. Gouzi, M. Hayot, P. Pomiès, and P. Berger. 2023.

J Cachexia Sarcopenia Muscle. 2023. doi:10.1002/jcsm.13103.

2022

Muscarinic receptor M3 activation promotes fibrocytes contraction.

Henrot, P., E. Eyraud, E. Maurat, S. Point, G. Cardouat, J-F. Quignard, P. Esteves, T. Trian, P-O Girodet, R. Marthan, M. C. Zysman, P. Berger, I. Dupin.

Frontiers in Pharmacology. 13. 2022 doi.org/10.3389/fphar.2022.939780.

Bronchial Remodeling-based Latent Class Analysis Predicts Exacerbations in Severe Preschool Wheezers.

Fayon M, Beaufils F, Esteves P, Campagnac M, Maurat E, Michelet M, Siao-Him-Fa V, Lavrand F, Simon G, Begueret H, Berger P.

Am J Respir Crit Care Med. 2022 Sep 15. doi: 10.1164/rccm.202205-0913OC.

Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients

Renaud Prevel, Raphaël Enaud, Arthur Orieux, Adrian Camino, Patrick Berger, Alexandre Boyer, Laurence Delhaes, Didier Gruson.

Crit Care. 2022 doi: 10.1186/s13054-022-03980-8.

Artificial intelligence in computed tomography for quantifying lung changes in the era of CFTR modulators.

Gael Dournes, Chase S Hall, Matthew M Willmering, Alan S Brody, Julie Macey, Stephanie Bui, Baudouin Denis de Senneville, Patrick Berger, François Laurent, Ilyes Benlala, Jason C Woods.

Eur Respir J. 2022 doi: 10.1183/13993003.00844-2021.

Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium

Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger

Cell Rep. 2022 doi: 10.1016/j.celrep.2022.110571.

Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients.

Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmée Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian

J Allergy Clin Immunol. 2022 doi: 10.1016/j.jaci.2022.01.022.

2021

Circulating fibrocytes as a new tool to predict lung cancer progression after surgery?

Henrot P, Beaufils F, Thumerel M, Eyraud E, Boudoussier A, Begueret H, Maurat E, Girodet PO, Marthan R, Berger P, Dupin I, Zysman M.

Eur Respir J. 2021 Sep 24:2101221. doi: 10.1183/13993003.01221-2021.

Unravelling the effects of omalizumab on fibrocytes.

Berger. P. and Dupin. I.

Respirology. 2021 doi:10.1111/resp.14115

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

Beaufils, F., P. Esteves, R. Enaud, O. Germande, A. Celle, R. Marthan, T. Trian, M. Fayon, and P. Berger.

J. Allergy Clin. Immunol. 2021 doi:10.1016/j.jaci.2021.03.027.

Evaluation of bronchial wall thickness in asthma using magnetic resonance imaging.

Benlala, I., G. Dournes, P.-O. Girodet, T. Benkert, F. Laurent, and P. Berger.

Eur. Respir. J. 2021 2100329. doi:10.1183/13993003.00329-2021.

Artificial intelligence in CT for quantifying lung changes in the era of CFTR modulators.

Dournes, G., C.S. Hall, M.M. Willmering, A.S. Brody, J. Macey, S. Bui, B. Denis-De-Senneville, P. Berger, F. Laurent, I. Benlala, and J.C. Woods.

Eur. Respir. J. 2021 2100844. doi:10.1183/13993003.00844-2021.

Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling.

Esteves, P., L. Blanc, A. Celle, I. Dupin, E. Maurat, N. Amoedo, G. Cardouat, O. Ousova, L. Gales, F. Bellvert, H. Begueret, M. Thumerel, J.-W. Dupuy, N. Desbenoit, R. Marthan, P.-O. Girodet, R. Rossignol, P. Berger, and T. Trian.

Eur. Respir. 2021 J. doi:10.1183/13993003.04252-2020.

Type 2-high asthma is associated with a specific indoor mycobiome and microbiome.

Vandenborght, L.-E., R. Enaud, C. Urien, N. Coron, P.-O. Girodet, S. Ferreira, P. Berger, and L. Delhaes.

J. Allergy Clin. Immunol. 2021 147:1296-1305.e6. doi:10.1016/j.jaci.2020.08.035.

2020

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks.

Enaud R, Prevel R, Ciarlo E, Beaufils F, Wieërs G, Guery B, Delhaes L.

Front Cell Infect Microbiol. 2020 Feb 19;10:9. doi: 10.3389/fcimb.2020.00009. eCollection 2020.

Bnip3 as a potential target to treat airway smooth muscle remodeling in asthma?

Beaufils F, Marthan R, Berger P.

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L212. doi: 10.1152/ajplung.00431.2019

Quantification of MRI T2-weighted High Signal Volume in Cystic Fibrosis: A Pilot Study.

Benlala I, Hocke F, Macey J, Bui S, Berger P, Laurent F, Dournes G.

Radiology. 2020 Jan;294(1):186-196. doi: 10.1148/radiol.2019190797. Epub 2019 Oct 29.

Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis.

Soret P, Vandenborght LE, Francis F, Coron N, Enaud R, Avalos M, Schaeverbeke T, Berger P, Fayon M, Thiebaut R, Delhaes L; Mucofong Investigation Group.Sci Rep. 2020 Feb 27;10(1):3589. doi: 10.1038/s41598-020-60015-4.

Asthmatic Bronchial Smooth Muscle Increases CCL5-Dependent Monocyte Migration in Response to Rhinovirus-Infected Epithelium.

Allard B, Levardon H, Esteves P, Celle A, Maurat E, Thumerel M, Girodet PO, Trian T, Berger P.

Front Immunol. 2020 Jan 6;10:2998. doi: 10.3389/fimmu.2019.02998. eCollection 2019.

Type 2-high asthma is associated with a specific indoor mycobiome and microbiome.

Vandenborght LE, Enaud R, Urien C, Coron N, Girodet PO, Ferreira S, Berger P, Delhaes L.

J Allergy Clin Immunol. 2020 Sep 12:S0091-6749(20)31248-3. doi: 10.1016/j.jaci.2020.08.035.

Reply.

Vandenborght LE, Enaud R, Urien C, Coron N, Girodet PO, Ferreira S, Berger P, Delhaes L.

J Allergy Clin Immunol. 2020 Dec 1:S0091-6749(20)31497-4. doi: 10.1016/j.jaci.2020.10.021.

2019

Determination of reliable lung function parameters in intubated mice.

Bonnardel E, Prevel R, Campagnac M, Dubreuil M, Marthan R, Berger P, Dupin I.

Respir Res. 2019 Sep 14;20(1):211. doi: 10.1186/s12931-019-1177-9

Fibrocyte accumulation in the airway walls of COPD patients.

Dupin I, Thumerel M, Maurat E, Coste F, Eyraud E, Begueret H, Trian T, Montaudon M, Marthan R, Girodet PO, Berger P.

Eur Respir J. 2019 Jun 13. pii: 1802173. doi: 10.1183/13993003.02173-2018. [Epub ahead of print]

Chemokines in COPD: From Implication to Therapeutic Use.

Henrot P, Prevel R, Berger P, Dupin I.

Int J Mol Sci. 2019 Jun 6;20(11). pii: E2785. doi: 10.3390/ijms20112785. Review.

Automated Volumetric Quantification of Emphysema Severity by Using Ultrashort Echo Time MRI: Validation in Participants with Chronic Obstructive Pulmonary Disease.

Benlala I, Berger P, Girodet PO, Dromer C, Macey J, Laurent F, Dournes G.

Radiology. 2019 Jul;292(1):216-225. doi: 10.1148/radiol.2019190052. Epub 2019 Jun 4

Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances.

Enaud R, Hooks KB, Barre A, Barnetche T, Hubert C, Massot M, Bazin T, Clouzeau H, Bui S, Fayon M, Berger P, Lehours P, Bébéar C, Nikolski M, Lamireau T, Delhaes L, Schaeverbeke T.

J Clin Med. 2019 May 10;8(5). pii: E645. doi: 10.3390/jcm8050645

Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension.

Coste F, Benlala I, Dournes G, Dromer C, Blanchard E, Girodet PO, Montaudon M, Baldacci F, Picard F, Marthan R, Laurent F, Berger P.

Int J Chron Obstruct Pulmon Dis. 2019 Feb 11;14:381-389. doi: 10.2147/COPD.S177638. eCollection 2019.

CT evaluation of hyperattenuating mucus to diagnose allergic bronchopulmonary aspergillosis in the special condition of cystic fibrosis.

Refait J, Macey J, Bui S, Fayon M, Berger P, Delhaes L, Laurent F, Dournes G.

J Cyst Fibros. 2019 Feb 12. pii: S1569-1993(18)30902-0. doi: 10.1016/j.jcf.2019.02.002. Epub 2019 Feb 12

2018

3D ultrashort echo time MRI of the lung using stack-of-spirals and spherical k-Space coverages: Evaluation in healthy

volunteers and parenchymal diseases.

Dournes G, Yazbek J, Benhassen W, Benlala I, Blanchard E, Truchetet ME, Macey J, Berger P, Laurent F.

J Magn Reson Imaging. 2018 Dec;48(6):1489-1497. doi: 10.1002/jmri.26212. Epub 2018 Sep 11.

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis.

Enaud R, Vandenborght LE, Coron N, Bazin T, Prevel R, Schaeverbeke T, Berger P, Fayon M, Lamireau T, Delhaes L.

Microorganisms. 2018 Mar 9;6(1). pii: E22. doi: 10.3390/microorganisms6010022. Review.

Montelukast reverses airway remodeling in actively sensitized young mice.

Debelleix S, Siao-Him Fa V, Begueret H, Berger P, Kamaev A, Ousova O, Marthan R, Fayon M.

Pediatr Pulmonol. 2018 Jun;53(6):701-709. doi: 10.1002/ppul.23980. Epub 2018 Mar 1.

Fibrocytes in Asthma and Chronic Obstructive Pulmonary Disease: Variations on the Same Theme.

Dupin I, Contin-Bordes C, Berger P.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):288-298. doi: 10.1165/rcmb.2017-0301PS. Review.

2017

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis: MR Imaging of Airway Mucus Contrasts as a Tool for Diagnosis.

Dournes G, Berger P, Refait J, Macey J, Bui S, Delhaes L, Montaudon M, Corneloup O, Chateil JF, Marthan R, Fayon M, Laurent F.

Radiology. 2017 Oct;285(1):261-269. doi: 10.1148/radiol.2017162350. Epub 2017 May 22.

Nasal airway epithelial cell IL-6 and FKBP51 gene expression and steroid sensitivity in asthmatic children.

Fayon M, Lacoste-Rodrigues A, Barat P, Helbling JC, Nacka F, Berger P, Moisan MP, Corcuff JB.

PLoS One. 2017 May 11;12(5):e0177051. doi: 10.1371/journal.pone.0177051. eCollection 2017.

Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg CM, Girodet PO, Berger P, Kline JN, Chupp G, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators.

J Allergy Clin Immunol. 2017 Sep;140(3):710-719. doi: 10.1016/j.jaci.2016.11.038. Epub 2017 Jan 13.

2016

CT evaluation of small pulmonary vessels area in patients with COPD with severe pulmonary hypertension.

Coste F, Dournes G, Dromer C, Blanchard E, Freund-Michel V, Girodet PO, Montaudon M, Baldacci F, Picard F, Marthan R, Berger P, Laurent F.

Thorax. 2016 Sep;71(9):830-7. doi: 10.1136/thoraxjnl-2015-207696. Epub 2016 Apr 15.

Lung morphology assessment of cystic fibrosis using MRI with ultra-short echo time at submillimeter spatial resolution.

Dournes G, Menut F, Macey J, Fayon M, Chateil JF, Salel M, Corneloup O, Montaudon M, Berger P, Laurent F.

Eur Radiol. 2016 Nov;26(11):3811-3820. Epub 2016 Feb 2.

Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients.

Trian T, Allard B, Ozier A, Maurat E, Dupin I, Thumerel M, Ousova O, Gillibert-Duplantier J, Le Morvan V, Begueret H, Girodet PO, Marthan R, Berger P.

J Allergy Clin Immunol. 2016 Jun;137(6):1717-1726.e13. doi: 10.1016/j.jaci.2015.10.031. Epub 2015 Dec 11.

Blood fibrocytes are recruited during acute exacerbations of chronic obstructive pulmonary disease through a CXCR4-dependent pathway.

Dupin I, Allard B, Ozier A, Maurat E, Ousova O, Delbrel E, Trian T, Bui HN, Dromer C, Guisset O, Blanchard E, Hilbert G, Vargas F, Thumerel M, Marthan R, Girodet PO, Berger P.

J Allergy Clin Immunol. 2016 Apr;137(4):1036-1042.e7. doi: 10.1016/j.jaci.2015.08.043. Epub 2015 Oct 23.

Bronchial Smooth Muscle Remodeling in Nonsevere Asthma.

Girodet PO, Allard B, Thumerel M, Begueret H, Dupin I, Ousova O, Lassalle R, Maurat E, Ozier A, Trian T, Marthan R, Berger P.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):627-33. doi: 10.1164/rccm.201507-1404OC.

2015

Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study.

Guillien A, Puyraveau M, Soumagne T, Guillot S, Rannou F, Marquette D, Berger P, Jouneau S, Monnet E, Mauny F, Laplante JJ, Dalphin JC, Degano B.

Eur Respir J. 2016 Jan;47(1):95-103. doi: 10.1183/13993003.00153-2015. Epub 2015 Oct 9.

Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.

Pilecki B, Schlosser A, Wulf-Johansson H, Trian T, Moeller JB, Marcussen N, Aguilar-Pimentel JA, de Angelis MH, Vestbo J, Berger P, Holmskov U, Sorensen GL.

Thorax. 2015 Sep;70(9):862-72. doi: 10.1136/thoraxjnl-2014-206609. Epub 2015 Jun 2.

An age-wise comparison of human airway smooth muscle proliferative capacity.

Fayon M, Andrieux A, Bara I, Rebola M, Labbé A, Marthan R, Berger P.

PLoS One. 2015 Mar 23;10(3):e0122446. doi: 10.1371/journal.pone.0122446. eCollection 2015.

Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

Girodet PO, Dournes G, Thumerel M, Begueret H, Dos Santos P, Ozier A, Dupin I, Trian T, Montaudon M, Laurent F, Marthan R, Berger P.

Am J Respir Crit Care Med. 2015 Apr 15;191(8):876-83. doi: 10.1164/rccm.201410-1874OC.

House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.

Trian T, Allard B, Dupin I, Carvalho G, Ousova O, Maurat E, Bataille J, Thumerel M, Begueret H, Girodet PO, Marthan R, Berger P.

Am J Respir Crit Care Med. 2015 Mar 1;191(5):538-46. doi: 10.1164/rccm.201409-1582OC.

Computed tomographic measurement of airway remodeling and emphysema in advanced chronic obstructive pulmonary disease. Correlation with pulmonary hypertension.

Dournes G, Laurent F, Coste F, Dromer C, Blanchard E, Picard F, Baldacci F, Montaudon M, Girodet PO, Marthan R, Berger P.

Am J Respir Crit Care Med. 2015 Jan 1;191(1):63-70. doi: 10.1164/rccm.201408-1423OC.

Before

Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

Allard B, Bara I, Gilbert G, Carvalho G, Trian T, Ozier A, Gillibert-Duplantier J, Ousova O, Maurat E, Thumerel M, Quignard JF, Girodet PO, Marthan R, Berger P.

PLoS One. 2014 Feb 13;9(2):e86945. doi: 10.1371/journal.pone.0086945. eCollection 2014

Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy.

Flabeau O, Meissner WG, Ozier A, Berger P, Tison F, Fernagut PO.

Mov Disord. 2014 Mar;29(3):388-95. doi: 10.1002/mds.25804. Epub 2014 Jan 17.

A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma.

Garcia G, Magnan A, Chiron R, Contin-Bordes C, Berger P, Taillé C, Devouassoux G, de Blay F, Couderc LJ, Didier A, O'Callaghan DS, Girodet PO, Bourdeix I, Le Gros V, Humbert M.

Chest. 2013 Aug;144(2):411-419. doi: 10.1378/chest.12-1961

Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model.

Girodet PO, Ozier A, Carvalho G, Ilina O, Ousova O, Gadeau AP, Begueret H, Wulff H, Marthan R, Bradding P, Berger P.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):212-9. doi: 10.1165/rcmb.2012-0103OC. Epub 2012 Nov 29

CT attenuation of the bronchial wall in patients with asthma: comparison with geometric parameters and correlation with function and histologic characteristics.

Lederlin M, Laurent F, Portron Y, Ozier A, Cochet H, Berger P, Montaudon M.

AJR Am J Roentgenol. 2012 Dec;199(6):1226-33. doi: 10.2214/AJR.11.8396.

In vivo micro-CT assessment of airway remodeling in a flexible OVA-sensitized murine model of asthma.

Lederlin M, Ozier A, Dournes G, Ousova O, Girodet PO, Begueret H, Marthan R, Montaudon M, Laurent F, Berger P.

PLoS One. 2012;7(10):e48493. doi: 10.1371/journal.pone.0048493. Epub 2012 Oct 30.

Airway smooth muscle in asthma: just a target for bronchodilation?

Black JL, Panettieri RA Jr, Banerjee A, Berger P.

Clin Chest Med. 2012 Sep;33(3):543-58. doi: 10.1016/j.ccm.2012.05.002. Epub 2012 Jul 11. Review

[Prevention of COPD exacerbation: a fundamental challenge].

Roche N, Aguilaniu B, Burgel PR, Durand-Zaleski I, Dusser D, Escamilla R, Perez T, Raherison C, Similowski T; groupe d’expert « Exacerbations de BPCO ».

Rev Mal Respir. 2012 Jun;29(6):756-74. doi: 10.1016/j.rmr.2012.04.006. Epub 2012 Jun 6. Review. French.

Mean bronchial wall attenuation value in chronic obstructive pulmonary disease: comparison with standard bronchial parameters and correlation with function.

Lederlin M, Laurent F, Dromer C, Cochet H, Berger P, Montaudon M.

AJR Am J Roentgenol. 2012 Apr;198(4):800-8. doi: 10.2214/AJR.11.6895.

Adaptative capacity of mitochondrial biogenesis and of mitochondrial dynamics in response to pathogenic respiratory chain dysfunction.

Benard G, Trian T, Bellance N, Berger P, Lavie J, Espil-Taris C, Rocher C, Eimer-Bouillot S, Goizet C, Nouette-Gaulain K, Letellier T, Lacombe D, Rossignol R.

Antioxid Redox Signal. 2013 Aug 1;19(4):350-65. doi: 10.1089/ars.2011.4244. Epub 2012 Apr 19.

In Vivo Computed Tomography as a Research Tool to Investigate Asthma and COPD: Where Do We Stand?

Dournes G, Montaudon M, Berger P, Laurent F.

J Allergy (Cairo). 2012;2012:972479. doi: 10.1155/2012/972479. Epub 2012 Jan 11.

Role of YKL-40 in bronchial smooth muscle remodeling in asthma.

Bara I, Ozier A, Girodet PO, Carvalho G, Cattiaux J, Begueret H, Thumerel M, Ousova O, Kolbeck R, Coyle AJ, Woods J, Tunon de Lara JM, Marthan R, Berger P.

Am J Respir Crit Care Med. 2012 Apr 1;185(7):715-22. doi: 10.1164/rccm.201105-0915OC. Epub 2012 Jan 26.

The pivotal role of airway smooth muscle in asthma pathophysiology.

Ozier A, Allard B, Bara I, Girodet PO, Trian T, Marthan R, Berger P.

J Allergy (Cairo). 2011;2011:742710. doi: 10.1155/2011/742710. Epub 2011 Dec 11.

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

Trian T, Burgess JK, Niimi K, Moir LM, Ge Q, Berger P, Liggett SB, Black JL, Oliver BG.

PLoS One. 2011;6(5):e20000. doi: 10.1371/journal.pone.0020000. Epub 2011 May 17.

[Pathophysiology of asthma].

Ozier A, Bara I, Girodet PO, Marthan R, Berger P.

Rev Prat. 2011 Mar;61(3):339-45. French.

Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention.

Girodet PO, Ozier A, Bara I, Tunon de Lara JM, Marthan R, Berger P.

Pharmacol Ther. 2011 Jun;130(3):325-37. doi: 10.1016/j.pharmthera.2011.02.001. Epub 2011 Feb 17. Review.

Control maintenance can be predicted by exhaled NO monitoring in asthmatic patients.

Ozier A, Girodet PO, Bara I, Tunon de Lara JM, Marthan R, Berger P.

Respir Med. 2011 Jul;105(7):989-96. doi: 10.1016/j.rmed.2011.01.006. Epub 2011 Feb 3.

Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings.

Montaudon M, Lederlin M, Reich S, Begueret H, Tunon-de-Lara JM, Marthan R, Berger P, Laurent F.

Radiology. 2009 Dec;253(3):844-53. doi: 10.1148/radiol.2533090303. Epub 2009 Sep 29.

Airway remodeling in a mouse asthma model assessed by in-vivo respiratory-gated micro-computed tomography.

Lederlin M, Ozier A, Montaudon M, Begueret H, Ousova O, Marthan R, Berger P, Laurent F.

Eur Radiol. 2010 Jan;20(1):128-37. doi: 10.1007/s00330-009-1541-0. Epub 2009 Aug 14.

Bronchial morphometry in smokers: comparison with healthy subjects by using 3D CT.

Montaudon M, Berger P, Lederlin M, Marthan R, Tunon-de-Lara JM, Laurent F.

Eur Radiol. 2009 Jun;19(6):1328-34. doi: 10.1007/s00330-008-1284-3. Epub 2009 Jan 24.

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.

Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P.

J Immunol. 2008 Aug 15;181(4):2772-80

Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma.

Trian T, Benard G, Begueret H, Rossignol R, Girodet PO, Ghosh D, Ousova O, Vernejoux JM, Marthan R, Tunon-de-Lara JM, Berger P.

J Exp Med. 2007 Dec 24;204(13):3173-81. Epub 2007 Dec 3.

Bronchial measurement with three-dimensional quantitative thin-section CT in patients with cystic fibrosis.

Montaudon M, Berger P, Cangini-Sacher A, de Dietrich G, Tunon-de-Lara JM, Marthan R, Laurent F.

Radiology. 2007 Feb;242(2):573-81. Epub 2006 Dec 19.

Assessment of airways with three-dimensional quantitative thin-section CT: in vitro and in vivo validation.

Montaudon M, Berger P, de Dietrich G, Braquelaire A, Marthan R, Tunon-de-Lara JM, Laurent F.

Radiology. 2007 Feb;242(2):563-72. Epub 2006 Dec 19.

Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma.

Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P, Brightling CE.

Am J Respir Crit Care Med. 2006 Dec 1;174(11):1179-88. Epub 2006 Sep 7.

Increased secretion of leukemia inhibitory factor by immature airway smooth muscle cells enhances intracellular signaling and airway contractility.

Fayon M, Rebola M, Berger P, Daburon S, Ousova O, Lavrand F, Moukaïla B, Pujol W, Taupin JL, Labbé A, Molimard M, Marthan R.

Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L244-51. Epub 2006 Feb 17.

Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma.

El-Shazly A, Berger P, Girodet PO, Ousova O, Fayon M, Vernejoux JM, Marthan R, Tunon-de-Lara JM.

J Immunol. 2006 Feb 1;176(3):1860-8.

RNA interference decreases PAR-2 expression and function in human airway smooth muscle cells.

Trian T, Girodet PO, Ousova O, Marthan R, Tunon-de-Lara JM, Berger P.

Am J Respir Cell Mol Biol. 2006 Jan;34(1):49-55. Epub 2005 Sep 29.

Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment.

Berger P, Perot V, Desbarats P, Tunon-de-Lara JM, Marthan R, Laurent F.

Radiology. 2005 Jun;235(3):1055-64. Epub 2005 Apr 15.

BERGER Lab

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